1. Your Lie In April
The focus of Your Lie in April is on young musical prodigies who are thrust into maturity as a result of childhood trauma and chronic sickness. Violinist Kaori Miyazono, who appears healthy and vibrant, actually suffers from a fatal condition. Fans suggest that the illness may be Friedreich’s ataxia or autoimmune hemolytic anemia, but no one knows for sure.
As a result of Kaori’s condition, she is forced to keep her affections for protagonist Kousei Arima hidden from the rest of the world. Because she and Kousei go through hardships that most adults would find inconceivable, Your Lie in April is a deeply moving film.
Nagisa Furukawa has been afflicted with an unidentified hereditary sickness from birth, which has manifested itself in recurrent episodes of fever, weakness, and agony. Throughout Clannad, she is plagued by this disease, which prevents her from attending school or participating in other social activities. Her predicament worsens in Clannad: After Story, as she dies shortly after giving birth to her daughter Ushio.
Few anime manage to do anything unique with Nagisa’s story like Clannad. It is clear that when Nagisa expresses fear that she is a burden to her parents and inhibits them from reaching their dreams, they loudly state that she has done nothing of the sort. It’s good to see Nagisa’s parents clearly dismiss such thoughts, as it’s not unusual for persons with a chronic disease or handicap to feel like a burden.
3. Fruits Basket
In Fruits Basket, disease is a persistent presence. It affects Tohru’s father, Yuki, and Akito, all of whom have weak immune systems and asthmatic lungs.
Tohru, who lost her father recently, is terrified even the slightest illness could be fatal. Tohru is terrified when Yuki develops a cold and collapses from a lack of air, and her fears are only confirmed when he dies.
This tension is amplified in the anime adaptation thanks to the disease. Unlike in the manga, where Akito’s health problems are entirely fictitious, in the anime, they are quite genuine for the character. Akito is rendered unable to leave the house due to the curse that has turned the rest of the Sohma family into animals.
Akito lash out at their family, physically beating them and verbally berating them when they seek aspirations and relationships outside of the home. Akito blames their own terrible health on their part in the curse, and believes that the rest of the family owes them a huge debt of gratitude. He also dislikes the idea of their cursed family finding happiness and meaning in spite of their circumstances.
4. Fullmetal Alchemist: Brotherhood
While illness isn’t a major story factor in Fullmetal Alchemist: Brotherhood, it does play a role in the protagonist’s motivation. Some fans speculate that Trisha Elric died of tuberculosis after getting an unknown sickness, leaving her two young sons orphaned and desperate to bring her back. In order to accomplish this, they study as much alchemy as they can and try to transform a human into something else. As a result, Al loses his entire body while Ed loses one arm and one leg.
Illness is not just Trisha’s problem in this series. When Izumi Curtis tried to humanize herself, she irreversibly harmed her internal organs, causing her to cough up blood and suffer from dizziness on a regular basis. After losing someone to disease, FMA:B depicts how life changes for the surviving members of a family.
5. My Neighbor Totoro
Initially, My Neighbor Totoro depicts the narrative of two young children and the titular gentle giant as they go out into the natural world. Their mother is in the hospital with an unknown sickness that may or may not lead to her death, which is why Totoro and Catbus and all the other amazing creatures they encounter are so comforting to them. Totoro offers as a comfort and diversion for the girls while they comprehend the realities of their mother’s illness because they are too little to express themselves verbally.
6. Sword Art Online II
However, the second season’s second half focuses on virtual reality as a sort of rehabilitation, unlike the first half of the season, which does not focus on disease. By entering virtual reality on an almost constant basis, the Medicuboid machine allows critically ill patients to rest, receive treatment and escape their misery, allowing them to live a fuller life than they could in their own body.
The Medicuboid slows the progression of Yuuki Konno’s AIDS, but it is not a cure. As a result of her compromised immune system, she is unable to interact with other terminally ill people who share her situation. Also, Yuuki is given the opportunity to travel and build a real friendship with one of the show’s characters, Asuna.
7. The Ancient Magus’ Bride
Illness plays a key role in the plot of The Ancient Magus’ Bride, even though it is never explicitly mentioned. Known as a sleigh beggy, the protagonist, Chise Hatori, is a person who attracts magic. As a result of her body’s inability to handle the power, she seems weak and unwell. A dragon’s curse that makes her much sicker and threatens to kill her is also near the end of this series. If she doesn’t break it, she will die.
Joseph, the show’s main villain, is also afflicted by terrible bodily ailments. Joseph’s body does not function like an immortal’s because of a curse he received when he merged with Cartaphilus. Because his flesh is decaying away from his body, he spends millennia trying to keep it from happening. For the sake of his own sanity, Joseph conducts a never-ending series of experiments on others, completely oblivious to the consequences.
8. Looking Up At The Half-Moon
Yuuichi Ezaki has hepatitis A and resides in the hospital. Isolated from family and friends due to his condition, he’s bored to tears. While in the hospital, he comes across Rika Akiba. In spite of Rika’s temperament and Yuuichi’s inability to be patient, the two begin to form an emotional connection. Unfortunately, it may already be too late for them to enjoy one another. Rika has a congenital cardiac problem that killed her father and may kill her as well; it’s not a treatable ailment.
9. Full Moon O Sagashite
A professional vocalist is Mitsuki Koyama’s dream come true. The problem is that her body doesn’t agree! Her options are to have surgery and risk losing her voice, or to not treat the cancer and put her health in jeopardy. She’s confronted with a difficult decision. Her outlook on life changes when two death gods arrive to tell her that she only has a year left to live.
10. March Comes In Like A Lion
March Comes in features two characters. Chronically ill people are shown to care for each other by the likes of Like a Lion. At first, Harunobu Nikaidou appears to be an exuberant person who enjoys life. But beneath the surface, Harunobu has an incurable kidney condition that makes everyday living difficult for him. Despite his sickness, he continues to pursue his dual career as a shogi player and a children’s book author, and he has no intention of letting it interfere.
Kai Shimada, Nikaidou’s mentor, tells him to calm down and take care of himself because his excitement borders on recklessness. Another shogi player, Shimada, is afflicted with major health issues. Recurring digestive issues for Shimada make eating difficult and sometimes prohibit him from finishing shogi matches. Shimada tells Nikaidou to take better care of his own health, despite the fact that he isn’t always perfect at it.
11. Ef: A Tale Of Melodies
Shuichi Kuze learns he has a deadly form of cardiomyopathy. As a result of the news, he breaks up with his fiancée, donates most of his assets, and isolates himself from his social circle. For Kuze, who believes he will pass away within the year, his decline is something no one should have to witness. However, a teenage girl who happens to be visiting Kuze’s neighbor, Mizuki Hayama, has other plans. In a matter of days, she has fallen head over heels in love with the dying 30-year-old and is doing all in her power to get into his life. Initially, he rejects her because she is a minor and also because he wants to die peacefully, but as time goes on, they get more and more close.
The experimental procedure Kuze receives extends his life by a few years, giving him the opportunity to begin rebuilding his life and giving Mizuki the opportunity to grow up and be someone he can love back.
12. Digimon Adventure
Hikari Yagami, better known to Digimon fans as Kari Kamiya, has always had a sickly appearance. As a matter of fact, she is unable to attend summer camp with her brother, Taichi, because she is ill. So she doesn’t come up till the latter part of the series.
As a young child, Taichi’s parents assign him the responsibility of caring for his sick younger sister, Hikari. He drags his sister to the playground because he’s bored and doesn’t yet understand the ramifications of his actions. Hikari contracts pneumonia as a result of the exercise and is subsequently hospitalized. Taichi’s mother slaps him across the face, blaming him for Hikari’s illness despite the fact that they are both seven. Developing a concern about his sister’s health and a unique sense of responsibility to safeguard her as a result of this
13. Mawaru Penguindrum
Mawaru Penguindrum, a genuinely strange series, begins with an illness.
On an excursion to an aquarium, Himari Takakura succumbs to an unknown deadly illness. It was a penguin hat from the aquarium’s souvenir shop that brought Himari back to life. Her body is now a haven for an unidentified life form, which keeps her alive, but at a price. If her brothers want to keep her alive, they must find an object known as the Penguin Drum and bring it back to her.
14. Dragon Ball Z
An episode of Dragon Ball Z shows that even the greatest Saiyan warriors can fall victim to sickness. For whatever reason, Goku is infected with a virus that causes extreme chest pain and tiredness before leading to his demise. Another time, he dies from the ailment, which forces Future Trunks to fly back in time and give him an undeveloped medicine. Goku still gets sick, but thanks to Future Trunks’s assistance, he only misses 10 days of work.